Srebf2 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comSrebf2 CLIA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Srebf2(Gene name) > Rat

Srebf2 (Gene name),

Sterol regulatory element-binding protein 2 (Protein name ), SRBP2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Srebf2;

Protein name:

Sterol regulatory element-binding protein 2(SREBP-2);

Alternative:

Sterol regulatory element-binding transcription factor 2;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminus domain) with RNF139.

Function:

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.

Subcellular Location:

Processed sterol regulatory element-binding protein 2 Nucleus

Protein Attributes:

Sequence length:

1133

Sequence:

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1133:

AARTLEKVGD | RRSCSDCQQM | IVKLGGGTAI | AAS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q3T1I5

String:

Q3T1I5

STRING:

10116.ENSRNOP00000052893

KEGG:

rno:300095

UniGene:

Rn.41063

Pfam:

PF00010

Uniprot:

Q3T1I5

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ELISA Kit for Rat SREBP-2

Cat.:

E12196h

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Packing:

96T

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ELISA Kit for Rat SREBP-2

Cat.:

E12196r

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96T

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ELISA Kit for Rat SREBP-2

Cat.:

E12196m

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MSDS:

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Packing:

96T

CLIA Kit for Rat SREBP-2

Cat.:

U12196m

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MSDS:

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Packing:

96T

CLIA Kit for Rat SREBP-2

Cat.:

U12196r

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MSDS:

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Packing:

96T

CLIA Kit for Rat SREBP-2

Cat.:

U12196h

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Manual:

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Rat SREBP-2

Cat.:

P12196Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat SREBP-2

Protein for Rat SREBP-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Prostate.

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